用萘和氯乙酸合成萘乙酸的研究

采用单因素试验和正交试验相结合,对以三氯化铁为主催化剂,溴化钾为助催化剂,萘与氯乙酸为原料合成萘乙酸的反应过程进行了系统研究.结果表明,保持反应温度在200℃左右,反应时间为15 h,萘/氯乙酸的摩尔比为2.5,反应物/催化剂质量比为32.5,主催化剂/助催化剂摩尔比为1/5时,产品收率达53.9%.本研究较传统的合成萘乙酸法缩短了反应时间,提高了反应产率.

Synthesis of naphthylacetic acid by naphthalene and chloroacetic acid

In this paper, a method is adopted to combine a single-factor experiment with orthogonal experiment, and conducts a systeriaatic study on the synthesis reaction process of naphthylacetic acid. The process was served with ferric chloride as major catalyst and potassium as assistant catalyst. Our results showed that when the reaction temperature reaches about 200%, the reaction time lasts 15 hours, the molar ratio of naphthalene and chloroacetic acid is 2.5, the mass ratio of reactant and catalyst is 32.5, and the molar ratio of major catalyst and assistant catalyst is 1 to 5, the rate of production could reach 53.9%. This improved method requires less time for reaction, and increases reactive productivity than traditional method for synthesis of naphthylacetic acid.