Identification of Bphs,an autoimmune disease locus,as histamine receptor H1 |
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Authors: | Ma Runlin Z Gao Jianfeng Meeker Nathan D Fillmore Parley D Tung Kenneth S K Watanabe Takeshi Zachary James F Offner Halina Blankenhorn Elizabeth P Teuscher Cory |
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Affiliation: | Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China 100101. |
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Abstract: | Bphs controls Bordetella pertussis toxin (PTX)-induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity. We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice. Hrh1-/- mice are protected from VAASH, which can be restored by genetic complementation with a susceptible Bphs/Hrh1 allele, and experimental allergic encephalomyelitis and autoimmune orchitis due to immune deviation. Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization. |
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