Induction of Thyroid Proliferative Changes in Rats Treated with Antithyroid Compound |
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| Authors: | A. Fernandez Rodriguez H. Galera Davidson M. Salguero Villadiego A. Moreno Fernandez I. Martin Lacave J. Fernandez Sanz |
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| Affiliation: | Department of Pathology, University of Seville, Spain. |
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| Abstract: | This study was designed to investigate the histologic changes in goitrogen-induced thyroid growth of the rat. The animals were orally treated by 1% potassium perchlorate except the controls and were sacrificed in intervals ranging from 1 to 12 months. The thyroid weight increased progressively along the treatment and after 2 months showed a diffuse homogenous hypertrophy and hyperplasia of follicular cells, decreased amount of colloid and increased vascularity. After sixth month of treatment true nodules appeared with complex morphology. |
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