Reactivation of the paternal X chromosome in early mouse embryos |
| |
Authors: | Mak Winifred Nesterova Tatyana B de Napoles Mariana Appanah Ruth Yamanaka Shinya Otte Arie P Brockdorff Neil |
| |
Institution: | X inactivation group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London, W12 0NN, UK. |
| |
Abstract: | It is generally accepted that paternally imprinted X inactivation occurs exclusively in extraembryonic lineages of mouse embryos, whereas cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivation. Here we show that imprinted X inactivation, in fact, occurs in all cells of early embryos and that the paternal X is then selectively reactivated in cells allocated to the ICM. This contrasts with more differentiated cell types where X inactivation is highly stable and generally irreversible. Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|