Assessment by ELISA of passively acquired protection against infectious bursal disease virus in chickens |
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| Authors: | K J FAHEY J K CROOKS R A FRASER |
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| Institution: | CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria. |
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| Abstract: | The level of maternal antibody to infectious bursal disease (IBD) virus in the circulation of one-day-old layer strain chickens was found to be on average, 45% of the antibody titre in their respective dam, while the minimum ELISA titre which protected against a challenge of 1000 CID50 of virus was 400. Maternal antibody was found to disappear from the circulation of these crossbred chickens with a half-life of 6.7 days. From these data it is possible to estimate the ELISA titre necessary in vaccinated hens to provide the desired duration of passive protection; protection being assessed by an ELISA which measures IBD viral antigen in the bursa of Fabricius following challenge. |
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