体细胞重编程为诱导多能干细胞的研究进展

诱导多能干( induced pluripotent stem，iPS)细胞在维持多能的同时能够持续自我更新。由于诱导多能干细胞能够创造病人特异或者疾病特异的多能干细胞，这些细胞对于研究疾病的机理和药物的发现非常有用。作者主要从iPS细胞建立的优化、被重编程的细胞类型、iPS细胞的发育潜能、iPS细胞产生的2种模型及iPS细胞的应用等5个方面进行了综述。

Progress in Reprogramming Somatic Cells into Induced Pluripotent Stem Cells

Induced pluripotent stem(iPS) cells have the ability to self-renew while maintaining pluripotency. The generation of iPS cells would allow creation of patient-specific stem cells and disease-specific stem cells, they could be very useful to study various disease mechanisms and provide valuable tools for drug discovery. This article provides a review of recent progress in iPS cell research，including optimization methods to establish iPS cells，reprogrammed cell types，differentiation potential of iPS cells，elite and stochastic models for iPS cells，and applications of iPS cells.