Influence of subclinical nematodosis on the kinetic disposition of fenbendazole in buffaloes |
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| Authors: | A C Mathur P K Sanyal S Sarkar |
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| Institution: | (1) Faculty of Veterinary Science and Animal Husbandry, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, 743 152 Nadia, West Bengal;(2) Animal Disease Research Laboratory, National Dairy Development Board, Anand, 388 001 Guijarat, India |
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| Abstract: | The disposition kinetics of fenbendazole was studied in buffaloes subclinically infected with gastrointestinal nematodes. There was significantly reduced uptake of the drug in infected animals compared to uninfected controls. The pH of the duodenal liquor was highly alkaline compared to the acidic pH in uninfected animals. The egg count in the faeces never became zero though the numbers were reduced to a great extent compared to pre-treatment values. The influence of the host's physiology on the reduced bioavailability of fenbendazole is discussed.Abbreviations AUC
area under the concentration-time curve
-
C
max
peak concentration in plasma;
- e.p.g.
eggs per gram of faeces
- ETH-OFZ
ethyl oxfendazole
- FBZ
fenbendazole
- FBZ-SO2
fenbendazole sulphone
- FEC
faecal egg count
- HPLC
high-performance liquid chromatography
- OFZ
oxfendazole
-
T
1/2
half-life in plasma
-
T
max
time to peak concentration in plasma |
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| Keywords: | anthelmintic buffalo fenbendazole metabolites nematodosis oxfendazole pharmacokinetics |
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