Local anesthetics: significance of hydrogen bonding in mechanism of action |
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| Authors: | Sax M Pletcher J |
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| Affiliation: | Biocrystallography Laboratory, Veterans Administration Hospital, Pittsburgh, Pennsylvania 15240, USA. |
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| Abstract: | The action of local anesthetics is considered in terms of their ability to function as the donor in a hydrogen bond. The formation of a hydrogen-bonded complex between the drug and an acceptor group on the neural membrane is suggested as a feature in the action of local anesthetics. |
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