Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites |
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| Authors: | Fremeau Robert T Kam Kaiwen Qureshi Tayyaba Johnson Juliette Copenhagen David R Storm-Mathisen Jon Chaudhry Farrukh A Nicoll Roger A Edwards Robert H |
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| Affiliation: | Department of Neurology, Graduate Programs in Neuroscience and Cell Biology, University of California San Francisco School of Medicine, CA 94143, USA. |
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| Abstract: | Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal. |
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