异黄酮植物雌激素调控动物神经内分泌及生产性能的研究

本文综述了近10年来关于异黄酮类化合物(芒柄花素和大豆黄酮)对动物(大鼠、猪为主)一些生产性能的影响及神经内分泌参与的研究.建立了芒柄花素的放射免疫方法;经放免受体分析表明,异黄酮植物雌激素可与动物的乳腺、垂体、下丘脑的胞浆雌二醇受体竞争性结合,表现弱的雌激素样作用;诱发血中催乳素、生长激素和IGF-1水平升高,从而促进乳腺发育和泌乳量;使雄性动物血中辜酮水平升高,促使胎儿和产后生长加速;促进小鼠的体液免疫和细胞免疫功能,提高妊娠母猪的特异免疫反应和新生仔猪特异性抗体水平;对雌性动物抑制LH的释放;此外,对反刍动物研究表明,可直接影响瘤胃代谢.并对其神经内分泌机制进行了探讨.

Studies on the isoflavonic phytoestrogens controlling Animal Endocrine Function and Performance

Abstract This paper reviews the research works concerning the effects of isoflavonoids (formononetin anddaidzein) on the performance of swlne and rat and the mechanism involved, carried out in our laboratory. Ra-dioimmunoassy of formononetin has established; The results of radioreceptor assay indicated that isoflavonicphytoestrogen is competitively binding to the cytosal estradiol receptor in mammary gland, pituitary and hy-pothalamus in animals, and exhibiting weak estrogenic effect and inducing increased levels of plasma pro-lactin, growth hormone and IGF-1, therefore, promoting development of mammary gland and milk produc-tion; elevating the blood testosterone concentration of male animals; accelerating fetal and neonatal animalgrowth; improving the function of humoral and cell lmmunity, enhancing the specific immune reaction ofpregnant sows and piglets. Inhibiting the LH release in female. Isoflavonoid also directly affects the rumenmetabolism.