Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro |
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Authors: | Z J Lucas |
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Abstract: | The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine. |
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