| 蚓激酶研究进展 |
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| 引用本文： | 王承利,张贺,王洋,孙建广.蚓激酶研究进展[J].动物医学进展,2009,30(11):86-90. |
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| 作者姓名： | 王承利 张贺 王洋 孙建广 |
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| 作者单位： | 1. 沈阳军区总医院医学动物实验科,辽宁沈阳,110016
2. 海军92426部队海岸医院,山东青岛,266405 |
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| 基金项目： | 全军医学科学技术研究"十一五"计划项目 |
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| 摘 要： | 蚓激酶作为中药地龙(即蚯蚓)的主要抗凝、溶栓成分,经动物试验及临床观察证实具有良好的纤溶、抗凝、溶栓和改善血流变等药理作用,并取得了较理想的效果.蚓激酶具有不良反应小、安全性高、疗效较显著、生产成本低等优势.论文综述了蚓激酶的分离纯化、理化及酶学特性、纤溶作用机理及临床应用等方面的研究成果.
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| 关 键 词： | 蚓激酶 纤溶酶 酶学特性 临床应用 |
Progress on Lumbrokinase |
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| WANG Cheng-li,ZHANG He,WANG Yang,SUN Jian-guang.Progress on Lumbrokinase[J].Progress In Veterinary Medicine,2009,30(11):86-90. |
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| Authors: | WANG Cheng-li ZHANG He WANG Yang SUN Jian-guang |
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| Institution: | WANG Cheng-li1,ZHANG He1,WANG Yang1,SUN Jian-guang2 (1.Department of Laboratory Animal,General Hospital of Shenyang Military Region,Shenyang,Liaoning,110016,China,2.Navy 92426 Force Coast Hospital,Qingdao,Shandong,255405,China) |
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| Abstract: | Lumbrokinase which is the composition of earthworm has the function of anticoagulation and thrombolysis.Many animal experiments and clinical observation confirmed that lumbrokinase has satisfactory pharmacologic action of anticoagulation,thrombolysis and improving bloodstream lumbrokinase has some advantages,such as less adverse effect,better safety,significant curative effect and low production cost.The paper reviewed the progress of lumbrokinase on isolation and purification,the physical,chemical and enzy... |
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| Keywords: | lumbrokinase fibrinolysin enzymological characteristis clinical application |
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