Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae) |
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| Authors: | Senejoux François Demougeot Céline Kerram Parhat Aisa Haji Akber Berthelot Alain Bévalot Françoise Girard-Thernier Corine |
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| Affiliation: | 1. EA 4267, UFR des Sciences Médicales et Pharmaceutiques, Université de Franche-Comté, 25030 Besançon, France;2. Xinjiang Medical University, Urumqi, Xinjiang, PR China;3. Xinjiang Key Laboratory of Plant Resources and Natural Products Chemistry, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China |
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| Abstract: | Ziziphora clinopodioides Lam. (Lamiaceae) is traditionally used in Uighur's medicine for the treatment of hypertension. Our study determined and evaluated the bioactive compounds by performing an activity-guided fractionation of a hydroalcoholic extract of the whole plant, using an in vitro model of rat isolated thoracic aortic rings. Seven compounds were identified as active principles: acacetin, apigenin, chrysin, thymonin, acetovanillone, 4-hydroxyacetophenone and ethyl 4-coumarate. Apigenin, chrysin and ethyl 4-coumarate were found to be the most effective. Our results provide the first evidence that the vasodilation induced by Z. clinopodioides Lam. is mediated, at least in part, by phenolic components. |
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| Keywords: | Uighur traditional medicine Ziziphora clinopodioides Lam. Bioassay-guided fractionation Rat aortic rings Vasorelaxant Phenolic compounds |
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