Four new neolignans from the leaves of Tripterygium wilfordii |
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| Authors: | Cao Xu Li Chuang-Jun Yang Jing-Zhi Wei Bai-Xing Yuan Shao-Peng Luo Yong-Ming Hou Qi Zhang Dong-Ming |
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| Affiliation: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. 8119202@163.com |
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| Abstract: | Four new neolignans, wilfordiols A-D (1-4), together with five known compounds (5-9), were isolated from an aqueous extract of the dried leaves of Tripterygium wilfordii. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The anti-inflammation activities of compounds 1-9 were evaluated by the inhibitory effect on NO production, in vitro. |
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| Keywords: | Tripterygium wilfordii Neolignan Anti-inflammatory activity |
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