Anti-inflammatory and antinociceptive activities of Trewia polycarpa roots |
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Authors: | Chamundeeswari D Vasantha J Gopalakrishnan S Sukumar E |
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Institution: | Sri Ramachandra College of Pharmacy, Sri Ramachandra Medical College and Research Institute (Deemed University), Porur, Chennai-600 116, India. |
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Abstract: | The alcoholic extract of Trewia polycarpa roots, when administered orally to rats at doses of 50-400 mg/kg, exhibited a dose-dependent anti-inflammatory activity in both acute and chronic models. It also showed a significant antinociceptive action mice in the dose range of 25-200 mg/kg. The extract did not reveal any toxicity in rats up to a dose of 3.2 g/kg (p.o.). It showed the presence of terpenoids, alkaloids, flavonoids, quinones and glycosides on phytochemical screening. |
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Keywords: | Trewia polycarpa Anti-inflammatory activity Antinociceptive activity |
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