Effects of Negative Pressure Wound Therapy on Healing of Open Wounds in Dogs |
| |
Authors: | Marco Demaria DVM Bryden J. Stanley BVMS MVetSc Diplomate ACVS Joe G. Hauptman DVM MS Diplomate ACVS Barbara A. Steficek DVM PhD Diplomate ACVP Michele C. Fritz BSc LVT John M. Ryan MVB MRCVS Nathaniel A. Lam DVM Trevor W. Moore DVM Heather S. Hadley DVM |
| |
Affiliation: | 1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI;2. Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, MI;3. Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK |
| |
Abstract: | Objective: To compare the effect of negative pressure wound therapy (NPWT) with standard‐of‐care management on healing of acute open wounds in dogs. Study Design: Prospective, controlled, experimental study. Animals: Adult dogs (n=10). Methods: Full‐thickness 4 cm × 2 cm wounds were surgically created on each antebrachium and in each dog were randomized to receive either NPWT or standard wound dressings (CON) for 21 days. Dressing changes and wound evaluations were made at 8 time points. First appearance of granulation tissue, smoothness of granulation tissue, exuberance, percent epithelialization, and percent contraction were compared. Biopsies for histopathology were taken, and histologic scores determined, at 5 time points, and aerobic bacterial wound cultures performed at 2 time points. Results: Granulation tissue appeared significantly earlier, and was smoother and less exuberant in NPWT wounds compared with CON wounds. Percent contraction in NPWT wounds was less than CON wounds after Day 7. Percent epithelialization in NPWT wounds was less than CON wounds on Days 11, 16, 18, and 21. Histologic scores for acute inflammation were higher in NPWT on Day 3, and lower on Day 7, than CON wounds. Bacterial load was higher in NPWT on Day 7. Conclusion: NPWT accelerated appearance of smooth, nonexuberant granulation tissue; however, prolonged use of NPWT impaired wound contraction and epithelialization. |
| |
Keywords: | |
|
|