Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs |
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Authors: | M.S. Kraus K.M. Rassnick J.J. Wakshlag A.R.M. Gelzer A.S. Waxman A.M. Struble K. Refsal |
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Affiliation: | 1.Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY;2.Endocrine Diagnostic Section, College of Veterinary Medicine, Michigan State University, Lansing, MI;3.Present address: Veterinary Medical Center of Central NewYork, 5841 Bridge Street, Syracuse, NY 13057;4.Present address: SAGE Centers for Veterinary Medicine, 907 Dell Ave. Campbell, CA 95008 |
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Abstract: | BackgroundVitamin D plays a pivotal role in cardiac function, and there is increasing evidence that vitamin D deficiency is associated with the development of congestive heart failure (CHF) in people.HypothesisSerum vitamin D concentration is lower in dogs with CHF compared with unaffected controls and serum vitamin D concentration is associated with clinical outcome in dogs with CHF.AnimalsEighty‐two client‐owned dogs.MethodsIn this cross‐sectional study, we examined the association between circulating 25‐hydroxyvitamin D [25(OH)D], a measure of vitamin D status, and CHF in dogs. In the prospective cohort study, we examined whether 25(OH)D serum concentration was associated with clinical outcome in dogs with CHF.ResultsMean 25(OH)D concentration (100 ± 44 nmol/L) in 31 dogs with CHF was significantly lower than that of 51 unaffected dogs (123 ± 42 nmol/L; P = .023). The mean calculated vitamin D intake per kg of metabolic body weight in dogs with CHF was no different from that of unaffected dogs (1.37 ± 0.90 μg/kg metabolic body weight versus 0.98 ± 0.59 μg/kg body weight, respectively, P = .097). There was a significant association of serum 25(OH)D concentration on time to clinical manifestation of CHF or sudden death (P = .02).Conclusion and Clinical RelevanceThese findings suggest that low concentrations of 25(OH)D may be a risk factor for CHF in dogs. Low serum 25(OH)D concentration was associated with poor outcome in dogs with CHF. Strategies to improve vitamin D status in some dogs with CHF may prove beneficial without causing toxicity. |
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Keywords: | 25‐ hydroxyvitamin D3, Canine, Cardiology |
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