MCM-41介孔二氧化硅/季铵化壳聚糖载烯啶虫胺纳米颗粒的制备及缓释性能

将MCM-41型介孔二氧化硅分散在烯啶虫胺(nitenpyram)水溶液中,借助超声作用使药物分子分散和进入MCM-41孔道中,利用硅羟基与季铵化壳聚糖(N-(2-羟基)丙基-3-三甲基氯化铵壳聚糖,HTCC)之间的静电作用力和氢键作用力,将HTCC包裹在nitenpyram@MCM-41的表面,从而把药物分子封装在孔道内,以减缓药物释放速率。利用扫描电子显微镜(SEM)、氮气吸附-脱附、透射扫描电子显微镜(TEM)、X射线衍射(XRD)、动态光散射激光粒度仪(DLS)和傅里叶红外光谱(FTIR)等对MCM-41和nitenpyram@MCM-41/HTCC纳米颗粒的结构、形貌和Zeta电位等参数进行了表征,考察了nitenpyram@MCM-41/HTCC对烯啶虫胺的载药量和缓释性能。结果表明:HTCC能够很好地结合在nitenpyram@MCM-41表面,形成nitenpyram@MCM-41/HTCC纳米颗粒的外壳,载药量最大为2.8%,有良好的缓释性能。

Preparation and sustained-release performance of nitenpyram@MCM-41 mesoporous silica/HTCC nanoparticles

MCM-41 mesoporous silica was dispersed in nitenpyram aqueous solution. With further sonication, nitenpyram was absorbed and entered into the pores of MCM-41 MSNs. The efficient positively charged polymer (a quaternized chitosan, (N-(2-hydroxyl) propyl-3-trimethylammonium chitosan chloride, HTCC) coating was realized by the electrostatic interaction and hydrogen bonding between the silicon-hydroxyl groups on the silica nanoparticles and the HTCC. For the shell of HTCC, nitenpyram was encapsulated inside the pores of MSNs. So that a slow and sustained release was realized. The structures, morphologies and Zeta potential, etc. of MCM-41 MSNs and nitenpyram@MCM-41/HTCC nanoparticles were systematically studied using scanning electron microscopy (SEM), N₂ adsorption-desorption, transmission electron microscopy (TEM), X-ray diffraction assay (XRD), dynamic light scattering particle size analysis(DLS) and fourier transform infrared spectroscopy (FTIR). The adsorption capacity and release property of nitenpyram@MCM-41/HTCC nanoparticles were also evaluated. The results showed that, HTCC, successfully wrapped on the surface of nitenpyram@MCM-41 nanoparticles, was served as the shell of nitenpyram@MCM-41/HTCC nanoparticles. The loading content was 2.8%, and the novel nitenpyram@MCM-41/HTCC nanoparticles have good sustained-release performance.