Quantitation of indomethacin, naproxen, and ibuprofen in pharmaceutical dosage forms by first and second derivative ultraviolet spectrometry

First and second derivative ultraviolet spectrometric methods are described for the estimation of indomethacin, naproxen, and ibuprofen in pharmaceutical dosage forms. The proposed methods permit the rapid, precise, and accurate determination of indomethacin capsules BP, naproxen capsules, and ibuprofen tablets BP. Matrix interference is successfully corrected. The results obtained by first and second derivative techniques are in accord with those obtained by the official assay method.