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| 核酸适体及其在疫病诊断中的应用 | |
| 引用本文： | 祖立闯,王金良,李娇,沈志强.核酸适体及其在疫病诊断中的应用[J].动物医学进展,2011,32(7):80-84. |
| 作者姓名： | 祖立闯 王金良 李娇 沈志强 |
| 作者单位： | 1. 山东绿都生物科技有限公司,山东滨州,256600 2. 山东省滨州畜牧兽医研究院,山东滨州,256600 3. 山东绿都生物科技有限公司,山东滨州256600;山东省滨州畜牧兽医研究院,山东滨州256600 |
| 摘 要： | 核酸适体是采用指数富集配体的系统进化技术从随机单链寡核苷酸库中筛选出的能与靶物质高特异性、高亲和力结合的配体.因其具有亲和力高、特异性强、精确识别、易体外合成与修饰等优点,逐渐成为抗体的代替或补充试剂,已成功应用于生物芯片、生物传感器、分子信标等多种疫病诊断技术平台,显示出了良好的应用前景,在未来的疫病诊断中将发挥越来... |
| 关 键 词： | 核酸适体 指数富集配体的系统进化技术 疫病诊断 |
Nucleic Acid Aptamer and Its Application in Disease Diagnosis |
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| ZU Li-chuang,WANG Jin-liang,LI Jiao,SHEN Zhi-qiang.Nucleic Acid Aptamer and Its Application in Disease Diagnosis[J].Progress In Veterinary Medicine,2011,32(7):80-84. | |
| Authors: | ZU Li-chuang WANG Jin-liang LI Jiao SHEN Zhi-qiang |
| Institution: | ZU Li-chuang 1,WANG Jin-liang 2,LI Jiao1,SHEN Zhi-qiang1,2 (1.Shandong Lvdu Bio-Sciences and Technology Co.Ltd.,Binzhou,Shandong,256600,China,2.Shandong Binzhou Animal Science and Veterinary Medicine Academy,China) |
| Abstract: | Nucleic acid aptamers are ligands with high specificity and affinity for their targets,which are screened from large oligonucleotide pools by the systematic evolution of ligands by exponential enrichment(SELEX) technology.For their high specificity and affinity,accurate identification,easily synthesized and modified in vitro.Nucleic acid aptamers have become the substitutes or complement antibody reagents,and have been applied in the technology platforms for bio-chips,biosensors,molecular beacons detection,... |
| Keywords: | nucleic acid aptamer systematic evolution of ligands by exponential enrichment disease diagnosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |