| 间充质干细胞的免疫调节特性及其应用研究进展 |
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| 引用本文： | 杨学义,马西亚,周珍辉,向双云. 间充质干细胞的免疫调节特性及其应用研究进展[J]. 动物医学进展, 2011, 32(7): 89-93 |
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| 作者姓名： | 杨学义 马西亚 周珍辉 向双云 |
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| 作者单位： | 1. 洛阳师范学院生命科学系,河南洛阳,471022
2. 北京农业职业学院畜牧兽医系,北京,102442 |
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| 基金项目： | 河南省教育厅自然科学研究计划项目(2010B180019); 洛阳师范学院应用科学与技术研究基金项目(2009-YYJS-02); 河南省科技攻关项目(102102110156) |
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| 摘 要： | 间充质干细胞(MSCs)是一种具有自我复制和多向分化潜能的多能干细胞,具有低免疫原性和免疫抑制作用,并能优先归巢于损伤组织,促进组织修复.体内外研究显示MSCs可影响T细胞、B细胞、自然杀伤细胞、抗原提呈细胞等免疫细胞功能,减轻器官移植后免疫排斥,有望在移植免疫领域得到广泛应用.论文概述了间充质干细胞的生物学特性,免疫...
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| 关 键 词： | 间充质干细胞 免疫抑制 自身免疫性疾病 |
Progress on Immunodulatory Properties Stem Cells and Application of Mesenchymal |
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| YANG Xue-yi,MA Xi-ya,ZHOU Zhen-hui,XIANG Shuang-yun. Progress on Immunodulatory Properties Stem Cells and Application of Mesenchymal[J]. Progress In Veterinary Medicine, 2011, 32(7): 89-93 |
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| Authors: | YANG Xue-yi MA Xi-ya ZHOU Zhen-hui XIANG Shuang-yun |
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| Affiliation: | YANG Xue-yi1,MA Xi-ya1,ZHOU Zhen-hui2,XIANG Shuang-yun2(1.Department of Life Science,Luoyang Normal University,Luoyang,Henan,471022,China,2.Department of Animal Husbandry and Veterinary Medicine,Beijing Agricultural Vocation College,Beijing,102442,China) |
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| Abstract: | Mesenchymal stem cells(MSCs) are mainly derived from bone marrow,which have potential capability of self-renewal and multi-differentiation.Recent researches found thatMSCs have low immunogenicity and immuomodulatory properties and can affect immue cells,such as T cells,B cells,natural killer cells,antigen presenting cells and so on,by which alleviating the immune resistance after organ transplantation.The present paper outlined the progress on the biological characteristic,immunosuppression function and the... |
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| Keywords: | mesenchymal stem cell immunosuppression autoimmune disease |
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