The use of compound 48/80 as a positive control in equine intradermal allergy testing |
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| Authors: | Shipstone Mueller Bettenay Mason & Friend |
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| Institution: | Animal Skin and Allergy Clinic, 70 Blackburn Road, Mt Waverley 3149, Melbourne, Australia,;Dorevitch Tresize Pathology, Melbourne, Australia,;Central Veterinary Diagnostic Laboratory. Melbourne, Australia |
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| Abstract: | The macroscopic and microscopic effects following the intradermal injection of the mast cell degranulator compound 48/80 were investigated in horses. It was found that a 1000 μg mL?1 solution of compound 48/80 could be used as an alternative to histamine as a positive control in equine intradermal allergy tests. An inflammatory cell infiltration was noted on histological examination, following compound 48/80 injection. This inflammatory cell pattern was similar to that noted for Type-I hypersensitivity. |
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| Keywords: | compound 48/80 equine hypersensitivity skin testing |
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