牛心朴子总生物碱对小鼠亚急性毒性试验的病理组织学观察

目的]研究牛心朴子总生物碱对小鼠的亚急性毒性试验效果，为开发利用牛心朴子资源提供理论依据。方法]将32只小鼠按灌药剂量分为12、24、48mg／ksbw3个试验组（低、中、高剂量组）和一个蒸馏水对照组（0．5ml／d），连续给药30d进行亚急性毒性试验，观察各脏器病理组织学切片。结果]各组动物未见明显的中毒症状和死亡。低剂量组、中剂量组小鼠的各器官均未发现明显细胞病变，高剂量组小鼠表现出比较明显的病理变化。结论]在该小鼠亚急性毒性试验中，高浓度的牛心朴子总生物碱能引起小鼠的心、肝脏、胃、脾脏、肾脏、肺脏、卵巢出现不同程度的病变。

Histopathologic Observation of Cynanchum komarovii Total Alkaloid to Subacute Toxicity Test of Mice

Objective] The paper aimed to study the effect of Cynanchum komarovii total alkaloid to subacute toxicity test of mice.Method]32 mice were divided into a control group infused 0.5 ml/d distilled water,and three experimental groups (low,middle,high dose group) given medicine with the daily dose of 12,24,48 mg/kg bw in 30 days.After the subacute toxicity test,histopathologic sections of organs were observed.Result] The result showed that no evident poisoning symptom and no animal death after the test.Resul...