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Detection of Corynebacterium bovis infection in athymic nude mice from a research animal facility in Korea
Authors:Tae-Hyoun Kim  Dong-Su Kim  Ju-Hee Han  Seo-Na Chang  Kyung-Sul Kim  Seung-Hyeok Seok  Dong-Jae Kim  Jong-Hwan Park  Jae-Hak Park
Abstract:Corynebacterium (C.) bovis infection in nude mice causes hyperkeratosis and weight loss and has been reported worldwide but not in Korea. In 2011, nude mice from an animal facility in Korea were found to have white flakes on their dorsal skin. Histopathological testing revealed that the mice had hyperkeratosis and Gram-positive bacteria were found in the skin. We identified isolated bacteria from the skin lesions as C. bovis using PCR and 16S rRNA sequencing. To the best of our knowledge, this is the first report of C. bovis infection in nude mice from Korea.
Keywords:athymic nude mice  Corynebacterium bovis  hyperkeratosis
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