Using molecular markers for detecting domestication, improvement, and adaptation genes |
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Authors: | Bruce Walsh |
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Institution: | (1) Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA |
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Abstract: | Development of statistical tests to detect selection (strictly speaking, departures from the neutral equilibrium model) has
been an active area of research in population genetics over the last 15 years. With the advent of dense genome sequencing
of many domesticated crops, some of this machinery (which heretofore has been largely restricted to human genetics and evolutionary
biology) is starting to be applied in the search for genes under recent selection in crop species. We review the population
genetics of signatures of selection and formal tests of selection, with discussions as to how these apply in the search for
domestication and improvement genes in crops and for adaptation genes in their wild relatives. Plant domestication has specific
features, such as complex demography, selfing, and selection of alleles starting at intermediate frequencies, that compromise
many of the standard tests, and hence the full power of tests for selection has yet to be realized. |
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Keywords: | Selective sweeps Detecting selection Genomic scans |
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