Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, PR China;1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;3. Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100029, China;1. College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China;2. Zhejiang Chemical Industry Research Institute Co., Ltd., 387 Tianmushan Rd., Hangzhou 310023, China |
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| Abstract: | Six new 9,19-cycloartane triterpenes (1–6) were isolated from the aerial parts of Cimicifuga yunnanensis. The new chemical structures were determined by extensive analyses of 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first 9,19-cycloartane triterpenes characterized by CH3-18 shifting from C-13 to C-12 in the Cimicifuga spp. The evaluation of inhibition activity against human HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines indicated that compounds 1–6 showed different levels of cytotoxic activities with IC50 values ranging from 1.2 to 27.8 μm. |
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