Anti-inflammatory lignanamides from the roots of Solanum melongena L. |
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| Institution: | 1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People''s Republic of China;2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People''s Republic of China;3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People''s Republic of China;1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People''s Republic of China;2. Changzheng Hospital, Second Military Medical University, Shanghai 200003, People''s Republic of China;3. Department of Cell Biology, Second Military Medical University, Shanghai 200433, People''s Republic of China |
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| Abstract: | Four new lignanamides, melongenamides A–D (1–4), together with six known ones (5–10), were isolated from the roots of Solanum melongena L. Their structures were elucidated on the basis of 1D and 2D NMR experiments and by comparison of their spectroscopic and physical data with the literature values. Compounds 2–8 exhibited inhibitions of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values ranging from 16.2 to 58.5 μM. |
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