Two new sesquiterpenes from Artemisia sieversiana |
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| Institution: | 1. Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China;2. Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China;3. Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, PR China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China |
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| Abstract: | Two new sesquiterpenes, together with 32 known compounds(3–34), were isolated from Artemisia sieversiana Ehrhart ex willd. and the compounds 3–21 were isolated from this plant for the first time. The new compounds were elucidated as 2α,9α-dihydroxymuurol-3(4)-en-12-oic acid (1) and 13α-methyl-(5αH,6αH,7αH,8αH)-austricin 8-O-β-D-glucopyranoside (2), respectively. The structural identification of these compounds was mainly achieved by spectroscopic methods including 1D and 2D NMR techniques, and the structure of compound 1 was confirmed by a single crystal X-ray diffraction experiment. Compounds 1–2 were evaluated for cytotoxic activity in vitro against MCF-7, NCI-H460 and Hep-G2 cell lines, respectively. |
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