A potent acetylcholinesterase inhibitor from Pancratium illyricum L. |
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| Affiliation: | 1. Department of Pharmacy and Biotechnology, University of Bologna, via Irnerio 42, Bologna, Italy;2. Department of Natural Products, Plant Biology and Soil Science, Faculty of Pharmacy, Av. Diagonal 643, 08028 Barcelona, Spain;3. Department of Life Quality Sciences, University of Bologna, Corso Augusto 237, Rimini, Italy;4. Interacademic Union for Studying of Secondary Metabolites of Vegetal Origin (Co.S.Me.Se.), Viale Ignazio da Laconi 13, Cagliari, Italy;1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | Plants belonging to the Amaryllidaceae contain an exclusive group of alkaloids, known as sources of important biological activities. In the present work, Pancratium illyricum L., a species belonging to this family and endemic of Sardinia (Italy), was investigated for its alkaloid content. Fresh bulbs and leaves were processed separately. Standard extraction and purification procedures were applied to obtain fractions and compounds for GC–MS and NMR analysis. In addition to eight already known alkaloids (1–8), 11α-hydroxy-O-methylleucotamine (9) was isolated for the first time and its structure completely determined by one and two-dimensional 1H and 13C NMR spectroscopy. This new galanthamine-type compound exhibited a pronounced in vitro acetylcholinesterase (AChE) inhibitory activity (IC50 = 3.5 ± 1.1 μM) in comparison to the reference standard galanthamine hydrobromide (IC50 = 1.5 ± 0.2 μM). |
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