Phomopsidone A,a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123 |
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| Affiliation: | 1. Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, PR China;2. School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China;3. Basic Medicine College, Putian University, Putian, Fujian 351100, PR China;4. School of Life Sciences, Shandong University, Jinan, Shandong 250100, PR China;1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;2. Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;3. Guangdong Institute of Microbiology, Guangzhou 510070, China;4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;5. Department of Genetics, School of Basic Medical Sciences, Jilin University, Changchun 130021, China;1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China;2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;3. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China;1. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;2. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China;1. School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China;2. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, 99 South Road of Longkun Road, Haikou 571158, China;3. College of Marine Sciences, South China Agricultural University, 483 Wushan Road, Guangzhou 510642, China |
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| Abstract: | One novel pentacyclic depsidone containing an oxetane unit, phomopsidone A (1), together with the reported excelsione (also named as phomopsidone) (2), and four known isobenzofuranones (3–6) were isolated from the mangrove endophytic fungus Phomopsis sp. A123. Their structures were elucidated by 1D and 2D NMR spectroscopic analysis and high resolution mass spectrometry. The bioactivity assays showed that these compounds possess cytotoxic, antioxidant, and antifungal activities. |
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