Antibacterial anthranilic acid derivatives from Geijera parviflora |
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| Institution: | 1. Southern Cross Plant Science, Southern Cross University, PO Box 157, Lismore, NSW 2480, Australia;2. Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA 5095, Australia;3. School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia;4. Division of Research, Southern Cross University, PO Box 157, Lismore, NSW 2480, Australia |
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| Abstract: | Five anthranilic acid derivatives, a mixture I of three new compounds 11′-hexadecenoylanthranilic acid (1), 9′-hexadecenoylanthranilic acid (2), and 7′-hexadecenoylanthranilic acid (3), as well as a new compound 9,12,15-octadecatrienoylanthranilic acid (4) together with a new natural product, hexadecanoylanthranilic acid (5), were isolated from Geijera parviflora Lindl. (Rutaceae). Their structures were elucidated by extensive spectroscopic measurements, and the positions of the double bonds in compounds 1–3 of the mixture I were determined by tandem mass spectrometry employing ozone-induced dissociation. The mixture I and compound 5 showed good antibacterial activity against several Gram-positive strains. |
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