Triterpenoids and α-glucosidase inhibitory constituents from Salacia hainanensis |
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| Institution: | 1. School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People''s Republic of China;2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People''s Republic of China;1. Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;3. Department of Pharmaceutical Sciences, Zibo Vocational Institute, Zibo, Shandong 255314, China |
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| Abstract: | Thirteen triterpenoids (1–13), including two new lupane triterpenoids, salacinins A and B (1 and 2), as well as one new friedelane triterpenoid, salacinin C (3), were isolated from the roots and stems of Salacia hainanensis. The structures of new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, and MS experiments. Compound 1 possesses rare 2,3-seco-lupane skeleton. Compounds 4, 6 and 7 showed inhibitory effects on α-glucosidase in vitro. |
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