Chemical constituents of Morus alba L. and their inhibitory effect on 3T3-L1 preadipocyte proliferation and differentiation |
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| Affiliation: | 1. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China;2. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;3. Sanjiu Medical & Pharmaceutical Co., Ltd, Shenzhen 518029, China;1. Dipartimento di Scienze Agrarie, Forestali e Alimentari, Università degli Studi di Torino, Largo Braccini 2, 10095 Grugliasco (TO), Italy;2. CITAB—Centro de Investigação e de Tecnologias Agro-Ambientais e Biológicas, Universidade de Trás-os-Montes e Alto Douro, Quinta de Prados, Apartado 1013, 5001-801 Vila Real, Portugal;1. Institut Régional de Recherche en Agroalimentaire et Biotechnologie: Charles Viollette, EA1026, Université Lille 2, F-59000 Lille, France;2. EA GRIIOT, EA4481, Laboratoire de pharmacognosie, UFR Pharmacie, Université Lille 2, F-59000 Lille, France;3. GESVAB EA 3675, ISVV, Université de Bordeaux, F-33882 Villenave d''Ornon Cedex, France;4. Unité de recherche Œnologie, EA 4577, ISVV, Université de Bordeaux, F-33882 Villenave d''Ornon, France;5. USC 1366 Œnologie, Institut National de Recherche Agronomique, ISVV, F-33882 Villenave d''Ornon, France;6. Jardin Botanique Universitaire de Talence, Université de Bordeaux, F-33400 Talence, France |
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| Abstract: | Mulberry leaf, an important traditional Chinese medicine, possesses many biological activities, including effects of anti-obesity. However, which constituents of mulberry leaf are responsible for its anti-adipogenic action is unclear. This study primarily investigated the chemical constituents from mulberry leaf and their bioactivity on the proliferation and differentiation of 3T3-L1 preadipocytes. A new flavane derivative, (2S)-4′-hydroxy-7-methoxy-8-prenylflavan (1), together with twelve known compounds including three flavanes (2–4), three chalcones (5–7), two flavones (8–9), two benzofurans (10–11) and two coumarin (12–13) was isolated from mulberry leaf. The structure of the new compound was elucidated by various spectroscopic methods including UV, HR-ESI-MS, 1H and 13C NMR and CD. The results of activity screening showed that compound 2, 6 and 7 inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. |
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