Meroterpenes and azaphilones from marine mangrove endophytic fungus Penicillium 303# |
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| Affiliation: | 1. School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, People''s Republic of China;2. Department of Chemistry, College of Life Science and Technology, Jinan University, Guangzhou 510632, People''s Republic of China;3. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People''s Republic of China;4. Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510800, People''s Republic of China;5. School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, People''s Republic of China;1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China;2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;3. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China |
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| Abstract: | Three new metabolites (compounds 1–2 and 6), one azaphilone, and two meroterpenes, together with eleven known compounds have been isolated from a mangrove endophytic fungus, Penicillium 303#. Structure elucidation was achieved by 1D and 2D NMR spectroscopy. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD). Cytotoxic activities of new compounds 1–2 and 6 and compound 7were evaluated in vitro against human cancer lines MDA-MB-435, HepG2, HCT-116, and A549. Those compounds showed weak to moderate cytotoxic activities. |
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