New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius |
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| Institution: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;2. Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;3. Guangdong Institute of Microbiology, Guangzhou 510070, China;4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;5. Department of Genetics, School of Basic Medical Sciences, Jilin University, Changchun 130021, China;1. Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, PR China;2. School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China;3. Basic Medicine College, Putian University, Putian, Fujian 351100, PR China;4. School of Life Sciences, Shandong University, Jinan, Shandong 250100, PR China;1. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;2. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China;1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China;2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;3. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China;1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China;2. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, China |
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| Abstract: | Two new aromatic butyrolactones, flavipesins A (1) and B (2), two new natural products (3 and 4), and a known phenyl dioxolanone (5) were isolated from marine-derived endophytic fungus Aspergillus flavipes. The structures of compounds 1–5 were elucidated by 1D- and 2D-NMR and MS analysis, the absolute configurations were assigned by optical rotation and CD data, and the stereochemistry of 1 was determined by X-ray crystallography analysis. 1 demonstrated lower MIC values against Staphylococcus aureus (8.0 μg/mL) and Bacillus subtillis (0.25 μg/mL). 1 also showed the unique antibiofilm activity of penetration through the biofilm matrix and kills live bacteria inside mature S. aureus biofilm. |
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