New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance |
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| Institution: | 1. Hubei Key Laboratory of Resource Science and Chemistry in Chinese Medicine, Hubei university of Chinese Medicine, Wuhan 430061, China;2. Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China;3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;1. Research Center for Cell Fate Control and College of Pharmacy, Sookmyung Women''s University, Seoul 140-742, Republic of Korea;2. Department of Natural Medicine Resources, Semyung University, 65 Semyung-ro, Jecheon, Chungbuk 390-711, Republic of Korea |
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| Abstract: | Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4–6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, IR). The isolated compounds were evaluated for their cytotoxicity against human tumor cell lines HepG2, MCF-7, T98G and B16-F10. Compound 1 showed selective cytotoxicity against cell lines of MCF-7 and T98G, while compound 6 showed significant cytotoxicity to the all tested tumor cell lines with IC50 in the range from 8.46 to 22.68 μmol/L. |
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