Antioxidant neolignan and phenolic glucosides from the fruit of Euterpe oleracea |
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| Institution: | 1. TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China;2. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA;3. Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS, USA;4. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;1. School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan, People''s Republic of China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People''s Republic of China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People''s Republic of China |
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| Abstract: | Three new glucosides, namely, (–)-7R8S-7′,8′-dihydroxy-dihydrodehydroconiferyl alcohol-9-O-β-d-glucopyranoside (1), (+)-7S8R-7′,8′-dihydroxy-dihydrodehydroconiferyl alcohol-9-O-β-d-glucopyranoside (2) and 4-hydroxy-2-methoxyphenyl 1-O-6-(hydrogen 3-hydroxy-3-methylpentanedioate)]-β-d-glucopyranoside (3), along with 6 known compounds were isolated from the fruit of Euterpe oleracea Mart. Their structures were elucidated based on spectroscopic analyses including NMR, HR-ESI-MS and CD. All the isolated compounds demonstrated significant antioxidant activity and 2 displayed moderate cytotoxicity against HL-60 cells. |
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