Five new prenylated chalcones from Desmodium renifolium |
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| Institution: | 1. School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan, People''s Republic of China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People''s Republic of China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People''s Republic of China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. Department of Biochemistry, Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;3. School of Life Sciences, Yunnan University, Kunming 650091, PR China;1. TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China;2. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA;3. Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS, USA;4. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;1. Department of Chemistry, Higher Teachers'' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon;2. Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany |
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| Abstract: | Five unusual new prenylated chalcones, renifolins D–H (1–5), were isolated from whole Desmodium renifolium plants. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. All of the isolates were evaluated for cytotoxicity using five tumor cell lines. Compounds 2 and 3 exhibited cytotoxicity against A549 cells, with IC50 values of 2.8 and 2.2 μM, respectively. |
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