IgG response against infective larvae of Dirofilaria immitis in experimentally infected cats |
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Authors: | Prieto G McCall J W Venco L Genchi M Simon F Genchi C |
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Institution: | Laboratorio de Parasitología, Facultad de Farmacia, Salamanca, Spain. |
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Abstract: | Somatic antigens from third stage larvae of Dirofilaria immitis (SL3) were used to detect IgG response against heartworm infection in 8 experimentally infected cats. A moderate specific anti-SL3 IgG response was found one month post-infection. Afterwards, antibodies decreased reaching a basal level 4 months post-infection and remained at this level until the end of the study. 6 months post-infection. Western blot analysis showed specific recognition of polypeptides of 79, 73, 60, 52, 40 and 39 kDa by sera from infected cats 1 month post-infection, but not by sera taken prior to the infection. The low antigenicity of the SL3 antigen in the cat should allow the parasite to escape the host's immune response. |
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