The prokinetic effect of mosapride citrate on horse gastric emptying rates |
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Authors: | Okamura Koichi Sasaki Naoki Fukunaka Morito Yamada Haruo Inokuma Hisashi |
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Affiliation: | The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan. |
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Abstract: | The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was orally administered at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Delta13CO2), an indirect indicator for the rate of gastric emptying, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride may facilitate the gastric emptying in horses. |
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