海洋芽孢杆菌可湿性粉剂配方的优化

为提高海洋芽孢杆菌B-9987可湿性粉剂(WP)的润湿性和悬浮率,降低其pH值,通过助剂筛选、混料设计试验等方法优化了制剂配方。结果表明:以十二烷基硫酸钠作为该可湿性粉剂的助剂时,助悬浮及助润湿效果明显;通过混料设计试验确定了该可湿性粉剂固体介质的最佳配比(质量分数)为:十二烷基硫酸钠9.54%,轻质碳酸钙83.74%,高岭土6.72%;其预测悬浮率为75.15%,pH为8.62,润湿时间89.40 s,验证试验结果悬浮率为73.13%,pH 8.33,润湿时间100.00 s,二者比较接近。优化后的海洋芽孢杆菌可湿性粉剂不需经过高耗能的气流粉碎过程即可达到农药可湿性粉剂标准的要求,可明显降低生产成本。

Formulation optimization of Bacillus marinus wettable powder

To improve the suspensibility and wettability of Bacillus marinus B-9987 wettable powder(WP)and decrease the pH of B.marinus WP, the formulation of B.marinus WP was optimized by additives screening and mixture tests design. The results showed that addition of sodium dodecyl sulfate (SDS) could improve the suspension and wetting effects for B.marinus WP. Mixture design was used to determine the optimum mixture proportion for light calcium carbonate(LCC), kaolinite and SDS. The experimental data showed that the most suitable contents of SDS, LCC and kaolinite in B.marinus WP were 9.54%, 83.74 % and 6.72%, respectively. Under these conditions, predicted suspensibility, pH and wetting time of B.marinus WP was 75.15%, 8.62 and 89.40 s, respectively. Furthermore, the experimental suspensibility, pH and wetting time of B.marinus WP was 73.13%, 8.33 and 100.00 s, which were in good agreement with predicted. The optimized B.marinus B-9987 WP without energy-intensive milling even can meet the standards of wettable powder, which greatly reduces the cost of production.