加减血府逐瘀汤对慢性阻塞性肺疾病稳定期患者生活质量的影响

目的 观察加减血府逐瘀汤对瘀血阻络型慢性阻塞性肺疾病（COPD）稳定期患者的肺功能和生活质量的影响。方法 将瘀血阻络型COPD稳定期Ⅰ~Ⅲ级患者共80例，根据随机数字表法分为对照组和观察组，每组40例。对照组患者给予噻托溴铵粉吸入剂治疗，观察组患者在对照组的基础上加服加减血府逐瘀汤治疗，两组疗程均为2个月。观察两组患者治疗前后的1 s用力呼气量（FEV1）、最大通气量（MVV）、用力肺活量（FVC）、圣乔治呼吸问卷（SGRQ）、临床症状和体征的变化情况。结果 治疗后两组患者的FEV1、MVV均有所改善，但差异无统计学意义（P>0.05）；治疗后观察组患者FVC改善优于对照组（P<0.05）；治疗后两组患者SGRQ各项积分均有明显改善（P < 0.05，P < 0.01），且观察组改善优于对照组（P<0.01）；治疗后两组患者的临床症状和体征均有明显改善（P<0.05），且观察组在喘息、易感冒、气短方面的改善优于对照组（P<0.05）。结论 加减血府逐瘀汤联合西药对瘀血阻络型COPD稳定患者具有良好的疗效，能够改善患者的生活质量，值得临床推广应用。

Effect of Modified Xuefu Zhuyu Decoction on Quality of Life of Patients with Chronic Obstructive Pulmonary Disease

Objective To observe the effect of modified Xuefu Zhuyu decoction on stasis blocking channels type of chronic obstructive pulmonary disease (COPD) of patients with stable pulmonary function and quality of life. Methods 80 cases of stasis blocking channels type of COPD I~III level from January 2015 to January 2016 were selected, the patients were randomly divided into control group and treatment group, 40 cases in each group. The control group were treated with 18ug tiotropium bromide powder for inhalation; treatment group was treated with compound modified Xuefu Zhuyu decoction on the basis of the control group. Compared the forced expiratory volume forced expiratory volume in one second(FEV1), maximum ventilatory volume (MVV), forced vital capacity Capacity(FVC), St George''s respiratory questionnaire respiratory questionnaire(SGRQ), the changes of clinical symptoms and signs of the two groups. Results After treatment, FEV1 and MVV before and after treatment of two groups had not statistically significant (P>0.05), there was no difference between the two groups (P>0.05); SGRQ questionnaire results showed that compared with before treatment, the scores of two groups were significantly improved (P<0.05), and the treatment group was significantly better than the control group, the results were statistically significant (P<0.05); after treatment, the main symptoms and signs of the two groups were significantly improved (P<0.05), and compared with the control group, wheezing, colds, shortness of breath of treatment was significant improved (P<0.05). Conclusion Modified Xuefu Zhuyu decoction combined with western medicine has a good effect on the stasis blocking channels type of stable chronic obstructive pulmonary disease patients. The treatment can effectively improve the quality of life of patients and help to stable and improved patient''s condition, which is deserved clinical application.