大青叶中药饮片与配方颗粒的质量研究

目的 对比研究不同产地大青叶中药饮片与配方颗粒的质量和价格，为临床医生及患者用药提供参考依据。方法 采用HPLC测定大青叶中药饮片与配方颗粒中水溶性有效成分尿苷、鸟苷的含量；并进行不同产地大青叶中药饮片水溶性浸出物比较以及与大青叶配方颗粒价格的比较。结果 5种不同产地大青叶中药饮片的尿苷、鸟苷含量及水溶性浸出物均存在差异，大青叶饮片以安徽、河北产地为最高；4种大青叶配方颗粒水溶性成分尿苷、鸟苷含量无显著差异，且与安徽、河北两地大青叶中药饮片中尿苷、鸟苷含量基本一致；相同剂量的配方颗粒的价格为传统中药饮片价格的1.5~2.5倍。结论 大青叶传统饮片质量以安徽、河北的为佳，与大青叶配方颗粒质量基本一致而价格较低。临床中可以综合考虑患者用药方便及经济承受能力，酌情选用大青叶传统中药饮片或配方颗粒。

Quality Research on Chinese Medicinal Pieces and Formula Granule of Folium Isatidis

Objective To determinate and compare the quality and price of Folium Isatidis pieces from different areas, and provide a reference for doctors or patients to elect different pieces types. Methods To study the quality on Chinese mdicical pieces of Folium Isatidis through detecting the conent of uridine and guanosine by HPLC and compare the amount of the water-soluble extraction of herbal pieces and their price of formula granule. Results The amount of water-solute extraction and the content of uridine and guanosine in traditional Folium Isatidis pieces samples from five areas were different, it was higher in Anhui and Hebei provinces. The content of effective opponents of Uridine and Guanosine in four guanule preparation was not different, it agreed with the traditional pieces from Anhui and Hebei. The price of the guanule preparation is 1.5-2.5 times of Folium Isatidis Chinese medicinal pieces. Conclusion The quality of traditional Folium Isatidis pieces in Anhui and Hebei is good, the amount of water-soluble extraction and the content of effective opponents in them is the same as the guanule preparation, but the price of them is lower than the guanule preparation. The pieces and formula granule of Folium Isatidis could be selected according to convenient useness of medicine and economic condition of patients.