3种血清肿瘤标志物在诊断大肠癌中的价值

目的：探讨癌胚抗原（CEA）、糖链抗原（CA199．casbohydrate antigen19-9）和CA242（casbohydrate antigen 242）在大肠癌的临床价值。方法：采用微粒酶免疫法（MEIA）检测30例大肠良性疾病及45倒大肠癌患者血清CEA，CA199和CA242的水平。结果：大肠癌患者与大肠良性疾病患者的CEA，CA199和CA242水平比较差异有显著性（P〈0．01～0．05）。血清CEA，CA199和CA242的水平随大肠癌病程的进展而逐渐升高；3种肿瘤标志物中以CA242敏感性和特异性最高．分别为60．3％和73．3％．3种肿瘤标志物对诊断的敏感性与大肠癌的分期有关；联合检测可使诊断的敏感性提高至83．6％。结论：血清CEA，CA199和CA242水平测定可应用于大肠癌的诊断和疗效的观察，并可用于监测肿瘤的复发和转移。肿瘤标志物的联合检测有助于大肠癌的早期诊断，并增加诊断的敏感性和特异性。

Three kinds of serum tumor markers in diagnosis of colon carcinoma

Objective: To investigate the clinical value of serum CEA, CA199 and CA242 levels in colon cancer. Methods: Serum CEA, CA199 and CA2 42 levels in 30 patients with benign colon diseases and 45 with colon carcinoma were detected by microne enzyme immunoassay. Results: Levels of CEA, CA199 and C A242 in cancer g roup were significantly higher than those in benign disease group (P<0.01 -0.05), especially in advanced cases. CA242 was the best diagnostic index among them, a nd its sensitivity and specificity were 60.3% and 73.3%, respectively. Their sen sitivity was related to tumor staging. Sensitivity of 3 markers was 83.6%. Concl usion: The combined assay of CEA, CAl9-9 and CA242 was helpful to early diagnosis of colon carcinoma.