| 黄芩苷对小鼠四氯化碳肝损伤保护作用的研究 |
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| 引用本文： | 宁康健,丁建华,代守志,章敏,吕锦芳. 黄芩苷对小鼠四氯化碳肝损伤保护作用的研究[J]. 畜牧与饲料科学, 2009, 30(1) |
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| 作者姓名： | 宁康健 丁建华 代守志 章敏 吕锦芳 |
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| 作者单位： | 安徽科技学院,安徽,凤阳,233100;安徽科技学院,安徽,凤阳,233100;安徽科技学院,安徽,凤阳,233100;安徽科技学院,安徽,凤阳,233100;安徽科技学院,安徽,凤阳,233100 |
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| 基金项目： | 安徽省科技厅年度重点项目(06023087C) |
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| 摘 要： | 探讨了黄芩苷对小鼠急性肝损伤的保护作用。将50只小鼠随机分成5组:对照组、模型组和黄芩苷低、中、高剂量组。黄芩苷组皮下注射不同剂量的黄芩苷注射液,用四氯化碳致小鼠急性肝损伤,观察小鼠采食量和饮水量、肝指数、血清及肝脏中谷丙转氨酶(ALT)活性和总蛋白(TP)、白蛋白(ALB)、球蛋白(GLO)含量。结果表明,黄芩苷各剂量组小鼠血清中ALT活性较模型组均明显降低(P<0.01),肝脏ALT活性较模型组均明显升高(P<0.01);其他指标差异不显著。结论:小鼠皮下注射黄芩苷对四氯化碳致肝损伤有一定的保护作用,且以中剂量为佳。
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| 关 键 词： | 黄芩苷 肝损伤 保护作用 小鼠 |
Study on the Protection of Baicalin on the Liver Injury Induced by Carbon Tetrachloride in Mice |
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| NING Kang-jian,et al. Study on the Protection of Baicalin on the Liver Injury Induced by Carbon Tetrachloride in Mice[J]. Animal Husbandry and Feed Science, 2009, 30(1) |
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| Authors: | NING Kang-jian et al |
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| Affiliation: | Anhui Science and Technology University;Fengyang 233100;China |
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| Abstract: | The protection of baicalin on the acute liver injury in mice was discussed. Fifty mice were divided into 5 groups of the control, model, low, moderate and high baicalin doses randomly. The baicalin groups were given different doses of baicalin injection by subcutaneous injection and the acute liver injury was induced by carbon tetrachloride in mice, then the feed intake, drinking amount, liver index, activities of ALT in serum and liver and the content of TP, ALB and GLO of mice were observed. The results i... |
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| Keywords: | baicalin liver injury protection mice |
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