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Correlation between pruritus score and grossly visible erythema in dogs
Authors:Peter Hill  Jan Rybní?ek  Peri Lau‐Gillard
Institution:1. Veterinary Specialist Centre, PO Box 307, North Ryde, NSW 1670, Australia;2. Veterinary Dermatology and Dermatopathology Service, Padochov 175, 664 91 Oslavany – Ivan?ice, Czech Republic;3. Division of Companion Animal Studies, Department of Clinical Veterinary Science, University of Bristol, BS40 5DU Bristol, UK
Abstract:The severity of pruritus and the extent and severity of erythema were quantified in 107 dogs presenting with various dermatoses. Pruritus was assessed using a previously validated scale, and erythema was quantified by assessing severity at 72 different body sites. Pruritus scores were either 0, or followed a normal type of distribution, with most dogs having a score in the middle of the range and a few dogs having low or high scores. The median pruritus score was 6.3/10. Erythema scores were heavily skewed towards lower values, with only a few dogs having high scores. The median diffuse erythema score was 6.0/216 and the median score for maculo‐papular/pustular erythema was 0/1080. Pruritus and erythema scores were significantly correlated with a Spearman rank correlation coefficient of 0.4062 (P < 0.001). However, visual assessment of the data representing the two variables revealed that this was not a consistent biological or clinically relevant correlation. Individual dogs could have a high pruritus score with low erythema score or vice versa. This study raises questions about the use of erythema scoring systems as a primary outcome measure in clinical trials, and also about the role of various inflammatory mediators in the pathogenesis of canine pruritus.
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