蛋氨酸羟基类似物的抑菌和酸化剂效果研究

采用单因子试验设计,研究了蛋氨酸羟基类似物(HMB,Rhodimet AT88)对有害微生物的抑菌和杀菌效果,以及对仔猪生产性能的影响。选用120头28日龄断奶的DLY仔猪,随机分为6个处理:HMB1.14、2.28、3.42 g/kg3个组,基础日粮组,DL-蛋氨酸1.0 g/kg组以及复合酸化剂3.0 g/kg组。结果表明:①HMB对大肠杆菌O8、O157、O149、鸡白痢沙门氏菌、坏死性肠炎梭菌的最低抑菌浓度为1000￣1400mg/kg,最低杀菌浓度为1200￣1400mg/kg;②HMB降低饲料系酸力,极显著降低仔猪腹泻率(P<0.01);③试验1￣6周,HMB1.14 g/kg和2.28 g/kg组显著提高仔猪生产性能(P<0.05);HMB2.28g/kg组效果优于复合酸化剂3.0g/kg组,显著高于DL-蛋氨酸1.0g/kg组(P<0.05)。HMB在断奶仔猪饲料中具有蛋氨酸和酸化剂双重效应。

Effects of 2-Hydroxy-4-(methylthio) Butanoic Acid on Inhibiting Pathogenic Microbes and Acidifier in Diet of Piglet

A single factor experiment was conducted to investigate the effects of 2-Hydroxy-4-(methylthio) butanoic acid(HMB,Rhodimet AT88)on pathogenic microbes tested by the tubes dilution method,and on growth performance of piglets as Met and acidifier in 8 weeks growth assay.A total of 120 weanling crossbred piglets were selectedinitially(7.0±0.5) kg and Duroc × Landrace ×Yorkshire],and were blocked by initial weight and sex and randomly allotted to 6 treatments containing control,HMB1.14,2.28 g/kg and 3.42 g/kg,DL-Met 1.0 g/kg,compound acidifier 3.0 g/kg,respectively.The results showed as follow: ① the mininum inhibitory concentration(MIC) of HMB for the Esherichia coli.O157,O8 O149,salmonella pullorium and clostridium perfringens were 1 000~1 400 mg/kg,and the minimum bactericidal concentration for them were 1 200~1 400 mg/kg;②HMB decreased the buffer capacity of the diet,and decreased significantly the diarrhea rate of piglets(P < 0.01);③During 1~6 weeks,compared to control,both HMB 1.14 g/kg and 2.28 g/kg increased the performance of piglets significantly(P < 0.05).The effects of HMB 2.28 g/kg was better than that of compound acidifier 3.0 g/kg,and markedly better than that of DL-Met 1.0 g/kg(P < 0.05).It implied that HMB can inhibit pathogenic microbes,and can be used as Met and acidifier to improve performance of piglets.