中国绿茶的抗肿瘤作用 Ⅰ.龙雾茶提取物抗癌体外实验

一定浓度的绿茶提取物,对人胃腺癌细胞具有明显的细胞毒作用,细胞抑制程度与提取物的剂量和接触时间成正相关;能够抑制肿瘤细胞DNA合成,阻止癌细胞由G_1期向S期移行,其阻断效应是发生在细胞分化的早期阶段;对致癌物质亚硝基吗啉的合成具有显著的阻断作用,阻断率为92.4％;对辐射损伤所产生的有害自由基具有明显的清除能力,因而具有防癌和抗癌作用。

Anticarcinogenic Activity of Chinese Green Tea I.In Vitro Studies on Anticarcinogenic Activity of the Extracts of Longwu Tea

Chinese Green Tea is one of the well-know traditioanl beverage can be traced back to thousands of years. The anticancer effects of the extracts (T-8750) from Longwu Tea, one of the variety of chinese green tea, was proved by the authors recently.It was found that T-8750 inhibited the clone growing of human gastric cancer cell line (BGC-823). It traversed the migration of cell line L_(1210)cyclefrom G_1 to S and played an important role in inhibiting DNA formation.Results showed that the blocking effects on the synthesis of carcinogen nitromorpholine was appeared in the early stage of differentation of cell. These phenomena are regarded as the major mechanism of killing the cancer cells.The blocking rate on the nitrosation of morpholine was 92.4%. Besides, it showed a significant scanvenging activity on the harmful free adicals produced during the process of radiation damage. Thug, the cancer-preventing effect and anticarcinogenic activity were observed.