| 益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性的研究 |
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| 引用本文： | 孙洁宇,高鹏飞,麻士卫,杜瑞亭,王明芳,邓承远,高杰,张和平. 益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性的研究[J]. 中国农业科技导报, 2009, 11(5): 77-82 |
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| 作者姓名： | 孙洁宇 高鹏飞 麻士卫 杜瑞亭 王明芳 邓承远 高杰 张和平 |
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| 作者单位： | (1.内蒙古农业大学乳品生物技术与工程教育部重点实验室, 呼和浩特 010018;2.内蒙古轻工科学研究所, 呼和浩特 010050) |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 通过研究益生菌Lactobacillus casei Zhang冻干粉对小鼠急性毒性作用,为该菌株的安全应用提供依据。连续14 d对小鼠灌胃不同剂量的L.casei Zhang冻干粉,各剂量组小鼠的一般体征、肝脏功能、脏器指数以及肝、肾、脾形态学的观察结果与对照组相比无显著差异（P>0.05）。急性毒性试验及相关指标检测结果显示L.casei Zhang冻干粉无毒副作用。
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| 关 键 词： | Lactobacillus casei Zhang；冻干粉；小鼠；急性毒性试验 |
| 收稿时间： | 2009-05-25 |
| 修稿时间： | 2009-07-20 |
Studies on Acute Toxicity of Lactobacillus casei Zhang Freeze-dried Powder in Mice |
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| SUN Jie-yu,GAO Peng-fei,MA Shi-wei,DU Rui-ting,WANG Ming-fang,DENG Cheng-yuan,GAO Jie,ZHANG He-ping. Studies on Acute Toxicity of Lactobacillus casei Zhang Freeze-dried Powder in Mice[J]. Journal of Agricultural Science and Technology, 2009, 11(5): 77-82 |
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| Authors: | SUN Jie-yu GAO Peng-fei MA Shi-wei DU Rui-ting WANG Ming-fang DENG Cheng-yuan GAO Jie ZHANG He-ping |
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| Affiliation: | (1.Key Laboratory of Dairy Biotechnology and Bioengineer, Ministry of Education, Inner Mongolia Agricultural University, ;Hohhot 010018|2.Inner Mongolia Light Industry Research Institute, Hohhot 010050, China) |
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| Abstract: | The acute toxicity of Lactobacillus casei Zhang freeze-dried powder was studied in mice to provide evidence for safety application. Different dose of L. casei Zhang freeze-dried powder were given to mice by gavage for 14 days. Compared with control, there were no significant differences (P>0.05) in general signs, liver function, organ index and morphology of liver, kidney and spleen of mice administrated with different dose of L. casei Zhang freeze-dried powder. The result of acute toxicity and determination of related indexes showed that L. casei Zhang freeze-dried powder had no toxicity and side effects. |
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| Keywords: | Lactobacillus casei Zhang |
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