| 香豆素肟酯衍生物的合成及抑菌活性 |
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| 引用本文： | 袁含笑,张文广,刘函如,张云天,张彩霞,郭孜怡,高艳清,雷鹏,刘西莉. 香豆素肟酯衍生物的合成及抑菌活性[J]. 农药学学报, 2022, 24(5): 1189-1195. DOI: 10.16801/j.issn.1008-7303.2022.0078 |
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| 作者姓名： | 袁含笑 张文广 刘函如 张云天 张彩霞 郭孜怡 高艳清 雷鹏 刘西莉 |
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| 作者单位： | 1.西北农林科技大学 植物保护学院，陕西 杨凌 712100 |
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| 基金项目： | 陕西省技术创新引导专项 (2020QFY07-03)；陕西省专项经费 (F2020221004)；省级大学生创新创业训练计划项目 (S202210712432). |
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| 摘 要： | 为发现具有高抑菌活性的肟酯类化合物, 结合本课题组前期研究, 设计并合成了18个新型香豆素肟酯衍生物, 并对抑菌活性及构效关系进行了研究。离体生物活性测定结果表明, 目标化合物在50 μg/mL下对番茄灰霉病菌、苹果树腐烂病菌和水稻纹枯病菌均表现出一定的抑制活性, 其中化合物 4n 对番茄灰霉病菌和水稻纹枯病菌的EC50值分别为4.44 μg/mL和3.65 μg/mL，表现出比香豆素和肟菌酯更优或相似的活性。
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| 关 键 词： | 香豆素 磺酸酯 肟酯 抑菌活性 水稻纹枯病菌 |
| 收稿时间： | 2022-07-06 |
Synthesis and antifungal activity of coumarin oxime esters |
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| Affiliation: | 1.College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China2.Shaanxi Research Center of Biopesticide Engineering & Technology, Yangling 712100, Shaanxi Province, China |
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| Abstract: | In order to discover high antifungal activity oxime esters compound, based on our previous studies, 18 novel coumarin oxime esters were designed and synthesized. The antifungal activity was evaluated and the structure-activity relationship was analyzed. The in vitro bioassay results showed that the target compounds showed antifungal activities against Botrytis cinerea, Valsa mali and Rhizoctonia solani. Especially, compound 4n displayed excellent activity against B. cinerea (EC50 = 4.44 μg/mL) and R. solani (EC50 = 3.65 μg/mL), which are better than or similar to those of coumarin and trifloxystrobin. |
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